Single-Dose Oral Antiviral Therapy Found To Accelerate Healing Time Of Cold Sore Outbreaks

Single-Dose Oral Antiviral Therapy Found To Accelerate Healing Time Of Cold Sore Outbreaks

You sense a tingling on your lip that, in a day or two, turns into a red blister. It’s a cold sore and it’s difficult to hide or get rid of easily.

With approximately 100 million episodes of recurrent cold sores occurring annually, all too many Americans are familiar with this common condition. Cold sores, medically known as herpes labialis, are an infection of the mouth area with the herpes simplex virus. In fact, it is estimated that cold sores affect 66 percent of American adults–with most being infected by the age of 20 years. Also known as fever blisters, cold sores typically appear as eruptions of small and usually painful blisters on the skin of the lips, mouth or gums or the skin around the mouth.

Although there is no cure for cold sores, new medical research found that a single dose of the prescription antiviral Famvir® (famciclovir tablets), given to patients with recurrent cold sores at the first sign of symptoms (within the first hour), resulted in significant improvements in healing time and resolution of pain and tenderness. This study is the first of its kind to show the benefit of a full course of antiviral therapy in a single dose when the virus is most active.

“These results are exciting news for the millions of people who suffer from cold sores each year. This research showed that Famvir was an effective treatment option that provides a full course of therapy in a single dose by taking the medication during the first few critical hours of an outbreak when the infection is most active,” said Dr. Spotswood Spruance, Professor of Medicine, Division of Infectious Diseases at the University of Utah School of Medicine, and lead investigator in the study. “The implications of this study are important to physicians because the results may have the potential to significantly influence the overall management of cold sore outbreaks.”

Dr. Spruance also noted that when the herpes virus is “triggered” in the body, it is most active during the first hours of a cold sore outbreak, creating a narrow window of opportunity for treatment. According to this research, when patients were treated with the oral antiviral Famvir during this critical period of time, it shortened the duration of outbreaks and hastened the resolution of symptoms associated with cold sore outbreaks in many patients.

Based on these findings, Novartis Pharmaceuticals Corporation, the maker of Famvir, filed a supplemental new drug application (sNDA) with the U.S. Food and Drug Administration (FDA) for a single-dose Famvir treatment indication for immunocompetent patients with recurrent herpes labialis (cold sores) in the fall of 2005.

Sixty-six percent of American adults are affected with cold sores, mostly women.

Note to Editors: For more information about genital herpes, go to www.genitalherpes.com. Famvir (famciclovir) tablets are indicated for the treatment or suppression of recurrent genital herpes in immunocompetent patients; the treatment of recurrent mucocutaneous herpes simplex infections in HIV-infected patients; and the treatment of acute herpes zoster (shingles).

In clinical trials, the most commonly reported adverse events vs. placebo were headache (zoster: 22.7% vs. 17.8; episodic: 23.6% vs. 16.4%; suppression: 39.3% vs. 42.9%); nausea (zoster: 12.5% vs. 11.6%; episodic: 10.0% vs. 8.0%); and diarrhea (zoster: 7.7% vs. 4.8%; suppression: 9.0% vs. 9.5%).

The efficacy of Famvir has not been established for initial-episode genital herpes infection, ophthalmic zoster, disseminated zoster, or in immunocompromised patients with herpes zoster. The safety and efficacy of Famvir for suppressive therapy have not been established beyond one year.

There is no cure for genital herpes. There is no evidence that Famvir can stop the spread of herpes to others.

Famvir, Pregnancy Category B, is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir® (penciclovir cream).

Auto Accessories – Cold Air Intakes

Auto Accessories – Cold Air Intakes

So lets talk about the whole theory of an intake and in particular
of a cold air intake. We all know that an engine mixes air and
fuel together, compresses it and then ignites the concoction,
that creates a small explosion in your cylinders. So in the digital
world the engine computer takes care of this concoction to the
best of it’s ability. Here is another piece of information, the
colder the air is, the denser it is. What does it mean to you? The
denser the air in the mix with fuel, the bigger the explosion in
your cylinders, the bigger the explosion in your cylinders, the
more horsepower you get. So we want to take advantage of
this and put in as cold (dense) air as we can in our cylinders to
create more horsepower.

Now to make a clarification of what a cold air intake really is and
what it is not. There are intakes that are called short or ram
intakes, and these are not considered cold air intakes. It is a
better performing air intake system since it involves a better
breathing filter and an intake tube that has less turns and kinks
to improve the intake of air to your engine. Yet, consider where
the a short or ram intake is placed; right next to the engine.
Well, if you haven’t noticed the engine produces heat and that
heat is kept in the engine compartment, thus when those short
or ram air intakes suck in air they are sucking in the hot air in
the engine compartment. Since hot air is less dense than cold
air, you may not be getting the best possible performance out of
engine.

Coming out of stage right, the cold air intake. Now there are
thousands of variations as to what a cold air intake looks like,
there is no real variation for what it does. The filter is put as far
away as possible from the engine where it can suck in ambient
air, which in most cases is colder than the air inside your engine
compartment. They are done in several ways, some have longer
intake tubes and are put either inside the fender or downwards
towards the ground to suck in fresh air. Some use a box that
prevents air from the engine compartment to enter so that in
can suck in air from the outside. Which ever company you
choose to buy this item from, buy from a reputable source. A
good reputable company invest plenty of money in research and
development to give you the best possible product and while
some may look the part, they don’t perform the part.

This has been a short introduction to a one of the favorite auto
accessories in the market: The Cold Air Intake. We will be
creating more articles about auto accessories in the future so
please visit us at the resource box below and make sure you
have the inside scoop on what is what in the auto modifiers
industry.